publication . Article . Other literature type . 2020

GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress

Clara Reglero; Vanesa Lafarga; Verónica Rivas; Ángela Albitre; Paula Ramos; Susana R. Berciano; Olga Tapia; María L. Martínez-Chantar; Federico Mayor Jr; Petronila Penela;
Open Access English
  • Published: 01 May 2020 Journal: Cancers (issn: 2072-6694, Copyright policy)
  • Publisher: MDPI AG
  • Country: Spain
Abstract
mRNA in hypoxic Hela cells. Interestingly, enhanced GRK2 and HuR expression correlate in luminal breast cancer patients. GRK2 also promotes the HuR/HIF-1&alpha
Subjects
free text keywords: beta-adrenergic signaling, BREAST-CANCER CELLS, HIF1 alpha, hypoxia, β-adrenergic signaling, breast cancer, mRNA regulation, nucleocytoplasmic shuttling, GRK2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, [beta]-Adrenergic Signaling, HuR, HIF1[alfa], VEGF, HIF1α, Article, Cancer Research, Oncology
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Article . 2020
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Article . 2020
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