PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

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Shrestha, Yashaswi; Schafer, Eric J.; Boehm, Jesse S.; Thomas, Sapana R.; He, Frank; Du, Jinyan; Wang, Shumei; Barretina, Jordi; Weir, Barbara A.; Zhao, Jean J.; Polyak, Kornelia; Golub, Todd R.; Beroukhim, Rameen; Hahn, William C.; (2011)
  • Publisher: Nature Publishing Group
  • Journal: Oncogene,volume 31,issue 29,pages3,397-3,408 (issn: 0950-9232, eissn: 1476-5594)
  • Related identifiers: pmc: PMC3291810, doi: 10.1038/onc.2011.515
  • Subject: PAK1 | Merlin | transformation | oncogene | MAPK | MET | Article

Activating mutations in the RAS family or BRAF frequently occur in many types of human cancers but are rarely detected in breast tumors. However, activation of the RAS-RAF-MEK-ERK Mitogen-Activated Protein Kinase (MAPK) pathway is commonly observed in human breast cance... View more