The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Alzheimer's Disease

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Messier, Claude; Teutenberg, Kevin;
  • Publisher: Hindawi Publishing Corporation
  • Journal: Neural Plasticity,volume 12,issue 4,pages311-328 (issn: 2090-5904, eissn: 1687-5443)
  • Related identifiers: doi: 10.1155/NP.2005.311, pmc: PMC2565470
  • Subject: Neurosciences. Biological psychiatry. Neuropsychiatry | RC321-571 | Article

Most brain insulin comes from the pancreas and is taken up by the brain by what appears to be a receptor-based carrier. Type 2 diabetes animal models associated with insulin resistance show reduced insulin brain uptake and content. Recent data point to changes in the in... View more
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