Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development

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Kowalewski-Nimmerfall, Elisabeth; Schähs, Philipp; Maresch, Daniel; Rendic, Dubravko; Krämer, Helmut; Mach, Lukas;
  • Publisher: Elsevier BV
  • Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, volume 1,843, issue 12, pages 2,900-2,912 (issn: 0167-4889)
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  • Identifiers: pmc: PMC4331662, doi: 10.1016/j.bbamcr.2014.08.012
  • Subject: Molecular Biology | PNGase F, Peptide N-glycosidase F | msCREG, Mouse CREG | Cathepsin | Proteolytic maturation | Article | LERP, Lysosomal enzyme receptor protein | Mannose 6-phosphate | Cell Biology | CREG, Cellular repressor of E1A-stimulated genes | M6P, Mannose 6-phosphate | GFP, Green fluorescent protein | Protein targeting | Lysosome | dCREG, D. melanogaster CREG | CREG
    mesheuropmc: fungi

Mammalian cellular repressor of E1A-stimulated genes is a lysosomal glycoprotein implicated in cellular growth and differentiation. The genome of the fruit fly Drosophila melanogaster encodes a putative orthologue (dCREG), suggesting evolutionarily conserved physiologic... View more
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