Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development

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Kowalewski-Nimmerfall, Elisabeth ; Schähs, Philipp ; Maresch, Daniel ; Rendic, Dubravko ; Krämer, Helmut ; Mach, Lukas (2014)
  • Publisher: Elsevier Pub. Co
  • Journal: Biochimica et Biophysica Acta, volume 1,843, issue 12, pages 2,900-2,912 (issn: 0006-3002)
  • Related identifiers: pmc: PMC4331662, doi: 10.1016/j.bbamcr.2014.08.012
  • Subject: Molecular Biology | PNGase F, Peptide N-glycosidase F | msCREG, Mouse CREG | Cathepsin | Proteolytic maturation | Article | LERP, Lysosomal enzyme receptor protein | Mannose 6-phosphate | Cell Biology | CREG, Cellular repressor of E1A-stimulated genes | M6P, Mannose 6-phosphate | GFP, Green fluorescent protein | Protein targeting | Lysosome | dCREG, D. melanogaster CREG | CREG
    mesheuropmc: fungi

Mammalian cellular repressor of E1A-stimulated genes is a lysosomal glycoprotein implicated in cellular growth and differentiation. The genome of the fruit fly Drosophila melanogaster encodes a putative orthologue (dCREG), suggesting evolutionarily conserved physiologic... View more
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