Activity of a Py-Im Polyamide Targeted to the Estrogen Response Element

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Nickols, Nicholas G.; Szablowski, Jerzy O.; Hargrove, Amanda E.; Li, Benjamin C.; Raskatov, Jevgenij A.; Dervan, Peter B.;

Pyrrole-imidazole (Py-Im) polyamides are a class of programmable DNA minor groove binders capable of modulating the activity of DNA-binding proteins and affecting changes in gene expression. Estrogen Receptor Alpha (ERα) is a ligand-activated hormone receptor that binds... View more
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