Inhibition of K+ Transport through Na+, K+-ATPase by Capsazepine: Role of Membrane Span 10 of the α-Subunit in the Modulation of Ion Gating

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Mahmmoud, Yasser A.; Shattock, Michael; Cornelius, Flemming; Pavlovic, Davor;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 9,issue 5 (eissn: 1932-6203)
  • Related identifiers: pmc: PMC4016139, doi: 10.1371/journal.pone.0096909
  • Subject: Enzyme Chemistry | Research Article | Biology and Life Sciences | Enzyme Regulation | Physiology | Hydrolases | Enzymes | Protein Chemistry | Enzymology | Electrophysiology | Proteins | Biochemistry | Transmembrane Transport Proteins | Biophysics

Capsazepine (CPZ) inhibits Na+,K+-ATPase-mediated K+-dependent ATP hydrolysis with no effect on Na+-ATPase activity. In this study we have investigated the functional effects of CPZ on Na+,K+-ATPase in intact cells. We have also used well established biochemical and bio... View more
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