Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial.

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Judit Villar-García ; Robert Güerri-Fernández ; Andrés Moya ; Alicia González ; Juan J Hernández ; Elisabet Lerma ; Ana Guelar ; Luisa Sorli ; Juan P Horcajada ; Alejandro Artacho ; Giuseppe D Auria ; Hernando Knobel
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 12, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0173802, pmc: PMC5384743
  • Subject: Microbial Pathogens | Research Article | Diagnostic Medicine | Bacteria | Signs and Symptoms | Pathology and Laboratory Medicine | Clostridium | Gut Bacteria | Saccharomyces | Immunodeficiency Viruses | Retroviruses | Genetics | Pathogens | HIV | Immune Response | Inflammation | Genomics | Immunology | Lentivirus | Viruses | Biology and Life Sciences | Microbiology | Medicine | Bacterial Pathogens | Microbiome | Microbial Genomics | Yeast | Medical Microbiology | Viral Pathogens | Q | R | RNA viruses | Fungi | Science | Organisms | Medicine and Health Sciences | Probiotics

Dysbalance in gut microbiota has been linked to increased microbial translocation, leading to chronic inflammation in HIV-patients, even under effective HAART. Moreover, microbial translocation is associated with insufficient reconstitution of CD4+T cells, and contribut... View more
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