Inhibition Mechanism of the Intracellular Transporter Ca2+-Pump from Sarco-Endoplasmic Reticulum by the Antitumor Agent Dimethyl-Celecoxib

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Ramón Coca; Fernando Soler; Ernesto Cortés-Castell; Vicente Gil-Guillén; Francisco Fernández-Belda;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 9,issue 7 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4086972, doi: 10.1371/journal.pone.0102083
  • Subject: Research Article | Biology and Life Sciences | Hydrolases | Enzymes | Medicine | Enzymology | Enzyme Kinetics | Q | R | Proteins | Science | Biochemistry | Transmembrane Transport Proteins
    mesheuropmc: skin and connective tissue diseases | lipids (amino acids, peptides, and proteins) | musculoskeletal diseases | heterocyclic compounds | organic chemicals

Dimethyl-celecoxib is a celecoxib analog that lacks the capacity as cyclo-oxygenase-2 inhibitor and therefore the life-threatening effects but retains the antineoplastic properties. The action mechanism at the molecular level is unclear. Our in vitro assays using a sarc... View more
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