Pharmacokinetic drug-drug interaction and their implication in clinical management

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Palleria, Caterina; DI PAOLO, Antonello; Giofrè, Chiara; Caglioti, Chiara; Leuzzi, Giacomo; Siniscalchi, Antonio; De Sarro, Giovambattista; Gallelli, Luca;
  • Publisher: Wolters Kluwer Medknow Publications
  • Journal: Journal of Research in Medical Sciences, volume 18, issue 7, pages 601-610 (issn: 1735-1995, eissn: 1735-7136)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC3897029
  • Subject: Review Article | drug-drug interactions | poly-therapy | R | excretion | Absorption | adverse drug reaction | Absorption; adverse drug reaction; distribution; drug-drug interactions; excretion; metabolism; poly-therapy | metabolism | Medicine | distribution

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and the... View more
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