Animal models for Gaucher disease research

Article English OPEN
Tamar Farfel-Becker; Einat B. Vitner; Anthony H. Futerman;
  • Publisher: The Company of Biologists
  • Journal: Disease Models & Mechanisms,volume 4,issue 6,pages746-752 (issn: 1754-8403, eissn: 1754-8411)
  • Related identifiers: pmc: PMC3209644, doi: 10.1242/dmm.008185
  • Subject: RB1-214 | R | Pathology | Medicine | Commentary

Gaucher disease (GD), the most common lysosomal storage disorder (LSD), is caused by the defective activity of the lysosomal hydrolase glucocerebrosidase, which is encoded by the GBA gene. Generation of animal models that faithfully recapitulate the three clinical subty... View more
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