Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways.

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Cho, Seok Hyun; Oh, Sun Young; Lane, Andrew P.; Lee, Joan; Oh, Min-Hee; Lee, Seakwoo; Zheng, Tao; Zhu, Zhou;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 9,issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0103685, pmc: PMC4121172
  • Subject: Allergies | Mouse Models | Biotechnology | Animal Models | Research Article | Molecular Cell Biology | Rhinology | Immunopathology | Immune Response | Immunology | Nasal Diseases | Biology and Life Sciences | Signal Transduction | Research and Analysis Methods | Physiology | Medicine | Genetic Engineering | Homeostasis | Q | R | Cell Biology | Model Organisms | Clinical Immunology | Cell Signaling | Science | Physiological Processes | Medicine and Health Sciences | Otorhinolaryngology
    mesheuropmc: respiratory system

Allergic rhinitis is a chronic inflammatory disease orchestrated by Th2 lymphocytes. Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 is known to be a negative regulator in the IL-4α/STAT-6 signaling pathway of the lung. However, the role of SHP-1 e... View more