Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

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HaiFang Yin; Prisca Boisguerin; Hong M Moulton; Corinne Betts; Yiqi Seow; Jordan Boutilier; Qingsong Wang; Anthony Walsh; Bernard Lebleu; Matthew JA Wood;
  • Publisher: Elsevier
  • Journal: Molecular Therapy: Nucleic Acids,volume 2,issue 9,pagee124 (issn: 2162-2531, eissn: 2162-2531)
  • Related identifiers: doi: 10.1038/mtna.2013.51, pmc: PMC4028018
  • Subject: Original Article | RM1-950 | chimeric peptide conjugate | antisense oligonucleotide | exon skipping | Therapeutics. Pharmacology | Duchenne muscular dystrophy

We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of morpholino phosphorodiam... View more
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