publication . Article . 2015

Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)

Amanda B. Spurdle; M. C. Pike; M. C. Pike; Xiaowen Liang; Christine M. Friedenreich; Marc T. Goodman; James R. Cerhan; Yong-Bing Xiang; Nicolas Wentzensen; Susan E. McCann; ...
Open Access English
  • Published: 17 Feb 2015 Journal: British Journal of Cancer, volume 112, issue 5, pages 925-933 (issn: 0007-0920, eissn: 1532-1827, Copyright policy)
  • Publisher: Nature Publishing Group
Abstract
Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes. Methods: We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results: Nulliparous women had an elevated endometrial cancer risk compar...
Subjects
free text keywords: Epidemiology, endometrial cancer, infertility, nulliparity, pooled analysis, Cancer Research, Oncology, Cohort, Gynecology, medicine.medical_specialty, medicine, Logistic regression, Odds ratio, medicine.disease, Cohort study, Risk factor, business.industry, business
Funded by
NIH| EPIDEMIOLOGIC STUDIES OF DIET AND CANCER HAWAII
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01CA033619-05
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Role of Genetic and Lifestyle Interplay in Uterus Cancer
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01CA098346-01A1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA083918-04
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| USC COMPREHENSIVE CANCER CENTER (CORE) SUPPORT
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30CA014089-17S1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Soyfood, gene polymorphisms and endometrial cancer risk
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA092585-05
  • Funding stream: NATIONAL CANCER INSTITUTE
43 references, page 1 of 3

The American Congress of Obstetricians and Gynecologists (ACOG) (2010 ACOG Practice Bulletin No. 110: noncontraceptive uses of hormonal contraceptives Obstet Gynecol 115 206 218 20027071 [PubMed]

Ali, AT. Reproductive factors and the risk of endometrial cancer. Int J Gynecol Cancer. 2014; 24: 384-393 [PubMed]

Althuis, MD, Moghissi, KS, Westhoff, CL, Scoccia, B, Lamb, EJ, Lubin, JH, Brinton, LA. Uterine cancer after use of clomiphene citrate to induce ovulation. Am J Epidemiol. 2005; 161: 607-615 [OpenAIRE] [PubMed]

Borgfeldt, C, Andolf, E. Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis. Acta Obstet Gynecol Scand. 2004; 83: 395-400 [OpenAIRE] [PubMed]

Brinton, LA, Berman, ML, Mortel, R, Twiggs, LB, Barrett, RJ, Wilbanks, GD, Lannom, L, Hoover, RN. Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol. 1992; 167: 1317-1325 [PubMed]

Brinton, LA, Gridley, G, Persson, I, Baron, J, Bergqvist, A. Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 1997; 176: 572-579 [OpenAIRE] [PubMed]

Brinton, LA, Melton, LJ, Malkasian, GD, Bond, A, Hoover, R. Cancer risk after evaluation for infertility. Am J Epidemiol. 1989; 129: 712-722 [PubMed]

Brinton, LA, Moghissi, KS, Westhoff, CL, Lamb, EJ, Scoccia, B. Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome). Fertil Steril. 2010; 94: 1787-1792 [OpenAIRE] [PubMed]

Brinton, LA, Sahasrabuddhe, VV, Scoccia, B. Fertility drugs and the risk of breast and gynecologic cancers. Semin Reprod Med. 2012; 30: 131-145 [OpenAIRE] [PubMed]

Brinton, LA, Sakoda, LC, Lissowska, J, Sherman, ME, Chatterjee, N, Peplonska, B, Szeszenia-Dabrowska, N, Zatonski, W, Garcia-Closas, M. Reproductive risk factors for endometrial cancer among Polish women. Br J Cancer. 2007; 96: 1450-1456 [OpenAIRE] [PubMed]

Brinton, LA, Sakoda, LC, Sherman, ME, Frederiksen, K, Kjaer, SK, Graubard, BI, Olsen, JH, Mellemkjaer, L. Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors. Cancer Epidemiol Biomarkers Prev. 2005; 14: 2929-2935 [PubMed]

Brinton, LA, Westhoff, CL, Scoccia, B, Lamb, EJ, Althuis, MD, Mabie, JE, Moghissi, KS. Causes of infertility as predictors of subsequent cancer risk. Epidemiology. 2005; 16: 500-507 [PubMed]

Cetin, I, Cozzi, V, Antonazzo, P. Infertility as a cancer risk factor—a review. Placenta. 2008; 29: 169-177 [OpenAIRE] [PubMed]

Chittenden, BG, Fullerton, G, Maheshwari, A, Bhattacharya, S. Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online. 2009; 19: 398-405 [OpenAIRE] [PubMed]

Cook LS Weiss NS Doherty JA Chen C 2006 Endometrial cancer Cancer Epidemiology and Prevention Schottenfeld D, Fraumeni JF, (eds) pp 1027 1043 Oxford University Press: New York, NY, USA

43 references, page 1 of 3
Abstract
Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes. Methods: We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results: Nulliparous women had an elevated endometrial cancer risk compar...
Subjects
free text keywords: Epidemiology, endometrial cancer, infertility, nulliparity, pooled analysis, Cancer Research, Oncology, Cohort, Gynecology, medicine.medical_specialty, medicine, Logistic regression, Odds ratio, medicine.disease, Cohort study, Risk factor, business.industry, business
Funded by
NIH| EPIDEMIOLOGIC STUDIES OF DIET AND CANCER HAWAII
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01CA033619-05
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Role of Genetic and Lifestyle Interplay in Uterus Cancer
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01CA098346-01A1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA083918-04
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| USC COMPREHENSIVE CANCER CENTER (CORE) SUPPORT
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30CA014089-17S1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Soyfood, gene polymorphisms and endometrial cancer risk
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA092585-05
  • Funding stream: NATIONAL CANCER INSTITUTE
43 references, page 1 of 3

The American Congress of Obstetricians and Gynecologists (ACOG) (2010 ACOG Practice Bulletin No. 110: noncontraceptive uses of hormonal contraceptives Obstet Gynecol 115 206 218 20027071 [PubMed]

Ali, AT. Reproductive factors and the risk of endometrial cancer. Int J Gynecol Cancer. 2014; 24: 384-393 [PubMed]

Althuis, MD, Moghissi, KS, Westhoff, CL, Scoccia, B, Lamb, EJ, Lubin, JH, Brinton, LA. Uterine cancer after use of clomiphene citrate to induce ovulation. Am J Epidemiol. 2005; 161: 607-615 [OpenAIRE] [PubMed]

Borgfeldt, C, Andolf, E. Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis. Acta Obstet Gynecol Scand. 2004; 83: 395-400 [OpenAIRE] [PubMed]

Brinton, LA, Berman, ML, Mortel, R, Twiggs, LB, Barrett, RJ, Wilbanks, GD, Lannom, L, Hoover, RN. Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol. 1992; 167: 1317-1325 [PubMed]

Brinton, LA, Gridley, G, Persson, I, Baron, J, Bergqvist, A. Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 1997; 176: 572-579 [OpenAIRE] [PubMed]

Brinton, LA, Melton, LJ, Malkasian, GD, Bond, A, Hoover, R. Cancer risk after evaluation for infertility. Am J Epidemiol. 1989; 129: 712-722 [PubMed]

Brinton, LA, Moghissi, KS, Westhoff, CL, Lamb, EJ, Scoccia, B. Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome). Fertil Steril. 2010; 94: 1787-1792 [OpenAIRE] [PubMed]

Brinton, LA, Sahasrabuddhe, VV, Scoccia, B. Fertility drugs and the risk of breast and gynecologic cancers. Semin Reprod Med. 2012; 30: 131-145 [OpenAIRE] [PubMed]

Brinton, LA, Sakoda, LC, Lissowska, J, Sherman, ME, Chatterjee, N, Peplonska, B, Szeszenia-Dabrowska, N, Zatonski, W, Garcia-Closas, M. Reproductive risk factors for endometrial cancer among Polish women. Br J Cancer. 2007; 96: 1450-1456 [OpenAIRE] [PubMed]

Brinton, LA, Sakoda, LC, Sherman, ME, Frederiksen, K, Kjaer, SK, Graubard, BI, Olsen, JH, Mellemkjaer, L. Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors. Cancer Epidemiol Biomarkers Prev. 2005; 14: 2929-2935 [PubMed]

Brinton, LA, Westhoff, CL, Scoccia, B, Lamb, EJ, Althuis, MD, Mabie, JE, Moghissi, KS. Causes of infertility as predictors of subsequent cancer risk. Epidemiology. 2005; 16: 500-507 [PubMed]

Cetin, I, Cozzi, V, Antonazzo, P. Infertility as a cancer risk factor—a review. Placenta. 2008; 29: 169-177 [OpenAIRE] [PubMed]

Chittenden, BG, Fullerton, G, Maheshwari, A, Bhattacharya, S. Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online. 2009; 19: 398-405 [OpenAIRE] [PubMed]

Cook LS Weiss NS Doherty JA Chen C 2006 Endometrial cancer Cancer Epidemiology and Prevention Schottenfeld D, Fraumeni JF, (eds) pp 1027 1043 Oxford University Press: New York, NY, USA

43 references, page 1 of 3
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