High-throughput screening for spermatogenesis candidate genes in the AZFc region of the Y chromosome by multiplex real time PCR followed by high resolution melting analysis

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Alechine, Evguenia; Corach, Daniel;
  • Publisher: Public Library of Science
  • Journal: volume 9,issue 5issn: 1932-6203, eissn: 1932-6203
  • Related identifiers: doi: 10.1371/journal.pone.0097227, pmc: PMC4020812
  • Subject: Molecular Genetics | Human Genetics | HRM | Research Article | Biology and Life Sciences | Genetics of Disease | Ciencias Biológicas | Medicine | Infertility | CIENCIAS NATURALES Y EXACTAS | Q | Y chromosome | R | Genetics | Bioquímica y Biología Molecular | Urology | Science | Spermatogenesis | Real Time PCR | Medicine and Health Sciences

Microdeletions in the AZF region of the Y chromosome are among the most frequent genetic causes of male infertility, although the specific role of the genes located in this region is not fully understood. AZFa and AZFb deletions impair spermatogenesis since no spermatoz... View more