publication . Article . Other literature type . 2007

Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1

Wu, Yuanming; Wang, Wengang; Díez-Sampedro, Ana; Richerson, George B.;
Open Access English
  • Published: 01 Dec 2007 Journal: Neuron, volume 56, issue 5, pages 851-865 (issn: 0896-6273, Copyright policy)
  • Publisher: Elsevier BV
Abstract
GABA transporters play an important but poorly understood role in neuronal inhibition. They can reverse, but this is widely thought to occur only under pathological conditions. Here we use a heterologous expression system to show that the reversal potential of GAT-1 under physiologically relevant conditions is near the normal resting potential of neurons, and that reversal can occur rapidly enough to release GABA during simulated action potentials. We then use paired recordings from cultured hippocampal neurons, and show that GABAergic transmission is not prevented by four methods widely used to block vesicular release. This nonvesicular neurotransmission was po...
Subjects
mesheuropmc: nervous system
free text keywords: Neuroscience(all), Article
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2007

Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1

Wu, Yuanming; Wang, Wengang; Díez-Sampedro, Ana; Richerson, George B.;