publication . Article . 2005

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease

Van Leuven Fred; Wera Stefaan; Van der Auwera Ingrid; Henderson Samuel T;
Open Access English
  • Published: 01 Oct 2005 Journal: Nutrition & Metabolism, volume 2, pages 28-28 (issn: 1743-7075, eissn: 1743-7075, Copyright policy)
  • Publisher: BioMed Central
Abstract
<p>Abstract</p> <p>Background</p> <p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did not examine high fat diets in combination with reduced carbohydrate intake. Here we tested the effect of a high saturated fat/low carbohydrate diet on a transgenic mouse model of AD.</p> <p>Results</p> <p>Starting at three months of age, two groups of female transgenic mice carrying the "London" APP mutation (APP/V717I) were fed either, a standar...
Subjects
free text keywords: Nutrition. Foods and food supply, Nutritional diseases. Deficiency diseases, TX341-641, RC620-627, Research
35 references, page 1 of 3

Evans, DA, Funkenstein, HH, Albert, MS, Scherr, PA, Cook, NR, Chown, MJ, Hebert, LE, Hennekens, CH, Taylor, JO. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. Jama. 1989; 262: 2551-2556 [PubMed] [DOI]

Hebert, LE, Scherr, PA, Bienias, JL, Bennett, DA, Evans, DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003; 60: 1119-1122 [PubMed] [DOI]

Selkoe, DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001; 81: 741-766 [OpenAIRE] [PubMed]

Stokin, GB, Lillo, C, Falzone, TL, Brusch, RG, Rockenstein, E, Mount, SL, Raman, R, Davies, P, Masliah, E, Williams, DS, Goldstein, LS. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005; 307: 1282-1288 [PubMed] [DOI]

Kalmijn, S, Launer, LJ, Ott, A, Witteman, JC, Hofman, A, Breteler, MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. 1997; 42: 776-782 [OpenAIRE] [PubMed] [DOI]

Grant, WB. Dietary links to Alzheimer's disease: 1999 update. J Alzheimers Dis. 1999; 1: 197-201 [PubMed]

Morris, MC, Evans, DA, Bienias, JL, Tangney, CC, Wilson, RS. Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology. 2004; 62: 1573-1579 [PubMed]

Morris, MC, Evans, DA, Bienias, JL, Tangney, CC, Bennett, DA, Aggarwal, N, Schneider, J, Wilson, RS. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 2003; 60: 194-200 [PubMed] [DOI]

Engelhart, MJ, Geerlings, MI, Ruitenberg, A, Van Swieten, JC, Hofman, A, Witteman, JC, Breteler, MM. Diet and risk of dementia: Does fat matter?: The Rotterdam Study. Neurology. 2002; 59: 1915-1921 [PubMed]

Refolo, LM, Malester, B, LaFrancois, J, Bryant-Thomas, T, Wang, R, Tint, GS, Sambamurti, K, Duff, K, Pappolla, MA. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000; 7: 321-331 [PubMed] [DOI]

Ho, L, Qin, W, Pompl, PN, Xiang, Z, Wang, J, Zhao, Z, Peng, Y, Cambareri, G, Rocher, A, Mobbs, CV, Hof, PR, Pasinetti, GM. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. Faseb J. 2004; 18: 902-904 [PubMed]

Levin-Allerhand, JA, Lominska, CE, Smith, JD. Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J Nutr Health Aging. 2002; 6: 315-319 [PubMed]

Shie, FS, Jin, LW, Cook, DG, Leverenz, JB, LeBoeuf, RC. Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport. 2002; 13: 455-459 [PubMed] [DOI]

George, AJ, Holsinger, RM, McLean, CA, Laughton, KM, Beyreuther, K, Evin, G, Masters, CL, Li, QX. APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiol Dis. 2004; 16: 124-132 [PubMed] [DOI]

Thio, LL, Sitzwohl, A, Trevathan, E, Kleinman RE, null. The ketogenic diet. American Academy of Pediatrics Pediatric Nutrition Handbook. 2002

35 references, page 1 of 3
Abstract
<p>Abstract</p> <p>Background</p> <p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did not examine high fat diets in combination with reduced carbohydrate intake. Here we tested the effect of a high saturated fat/low carbohydrate diet on a transgenic mouse model of AD.</p> <p>Results</p> <p>Starting at three months of age, two groups of female transgenic mice carrying the "London" APP mutation (APP/V717I) were fed either, a standar...
Subjects
free text keywords: Nutrition. Foods and food supply, Nutritional diseases. Deficiency diseases, TX341-641, RC620-627, Research
35 references, page 1 of 3

Evans, DA, Funkenstein, HH, Albert, MS, Scherr, PA, Cook, NR, Chown, MJ, Hebert, LE, Hennekens, CH, Taylor, JO. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. Jama. 1989; 262: 2551-2556 [PubMed] [DOI]

Hebert, LE, Scherr, PA, Bienias, JL, Bennett, DA, Evans, DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003; 60: 1119-1122 [PubMed] [DOI]

Selkoe, DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001; 81: 741-766 [OpenAIRE] [PubMed]

Stokin, GB, Lillo, C, Falzone, TL, Brusch, RG, Rockenstein, E, Mount, SL, Raman, R, Davies, P, Masliah, E, Williams, DS, Goldstein, LS. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005; 307: 1282-1288 [PubMed] [DOI]

Kalmijn, S, Launer, LJ, Ott, A, Witteman, JC, Hofman, A, Breteler, MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. 1997; 42: 776-782 [OpenAIRE] [PubMed] [DOI]

Grant, WB. Dietary links to Alzheimer's disease: 1999 update. J Alzheimers Dis. 1999; 1: 197-201 [PubMed]

Morris, MC, Evans, DA, Bienias, JL, Tangney, CC, Wilson, RS. Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology. 2004; 62: 1573-1579 [PubMed]

Morris, MC, Evans, DA, Bienias, JL, Tangney, CC, Bennett, DA, Aggarwal, N, Schneider, J, Wilson, RS. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 2003; 60: 194-200 [PubMed] [DOI]

Engelhart, MJ, Geerlings, MI, Ruitenberg, A, Van Swieten, JC, Hofman, A, Witteman, JC, Breteler, MM. Diet and risk of dementia: Does fat matter?: The Rotterdam Study. Neurology. 2002; 59: 1915-1921 [PubMed]

Refolo, LM, Malester, B, LaFrancois, J, Bryant-Thomas, T, Wang, R, Tint, GS, Sambamurti, K, Duff, K, Pappolla, MA. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000; 7: 321-331 [PubMed] [DOI]

Ho, L, Qin, W, Pompl, PN, Xiang, Z, Wang, J, Zhao, Z, Peng, Y, Cambareri, G, Rocher, A, Mobbs, CV, Hof, PR, Pasinetti, GM. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. Faseb J. 2004; 18: 902-904 [PubMed]

Levin-Allerhand, JA, Lominska, CE, Smith, JD. Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J Nutr Health Aging. 2002; 6: 315-319 [PubMed]

Shie, FS, Jin, LW, Cook, DG, Leverenz, JB, LeBoeuf, RC. Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport. 2002; 13: 455-459 [PubMed] [DOI]

George, AJ, Holsinger, RM, McLean, CA, Laughton, KM, Beyreuther, K, Evin, G, Masters, CL, Li, QX. APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiol Dis. 2004; 16: 124-132 [PubMed] [DOI]

Thio, LL, Sitzwohl, A, Trevathan, E, Kleinman RE, null. The ketogenic diet. American Academy of Pediatrics Pediatric Nutrition Handbook. 2002

35 references, page 1 of 3
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2005

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease

Van Leuven Fred; Wera Stefaan; Van der Auwera Ingrid; Henderson Samuel T;