publication . Article . 2017

Corticolimbic hyper-response to emotion and glutamatergic function in people with high schizotypy:a multimodal fMRI-MRS study

Modinos, G; McLaughlin, A; Egerton, A; McMullen, K; Kumari, V; Barker, G J; Keysers, C; Williams, S C R;
Open Access English
  • Published: 04 Apr 2017 Journal: volume 7, issue 4, page e1083eissn: 2158-3188, Copyright policy
  • Publisher: Nature Publishing Group
Abstract
Animal models and human neuroimaging studies suggest that altered levels of glutamatergic metabolites within a corticolimbic circuit have a major role in the pathophysiology of schizophrenia. Rodent models propose that prefrontal glutamate dysfunction could lead to amygdala hyper-response to environmental stress and underlie hippocampal overdrive in schizophrenia. Here we determine whether changes in brain glutamate are present in individuals with high schizotypy (HS), which refers to the presence of schizophrenia-like characteristics in healthy individuals, and whether glutamate levels are related to altered corticolimbic response to emotion. Twenty-one healthy...
Subjects
mesheuropmc: nervous system
free text keywords: Biological Psychiatry, Original Article, /dk/atira/pure/subjectarea/asjc/2700/2738, Cellular and Molecular Neuroscience, /dk/atira/pure/subjectarea/asjc/2800/2803, /dk/atira/pure/subjectarea/asjc/2800/2804, Journal Article, Psychiatry and Mental health
Funded by
EC| VICARIOUSBRAIN
Project
VICARIOUSBRAIN
Cracking the code and flow of empathy
  • Funder: European Commission (EC)
  • Project Code: 312511
  • Funding stream: FP7 | SP2 | ERC
,
RCUK| Neurobiology of response to clozapine in treatment resistant schizophrenia
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: MR/L003988/1
  • Funding stream: MRC
71 references, page 1 of 5

1 van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L. A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 2009; 39: 179-195.

2 Linscott RJ, van Os J. An updated and conservative systematic review and metaanalysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychol Med 2013; 43: 1133-1149.

3 Nelson MT, Seal ML, Pantelis C, Phillips LJ. Evidence of a dimensional relationship between schizotypy and schizophrenia: a systematic review. Neurosci Biobehav Rev 2013; 37: 317-327.

4 Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 1991; 17: 555-564.

5 Raine A. Schizotypal personality: neurodevelopmental and psychosocial trajectories. Annu Rev Clin Psychol 2006; 2: 291-326.

6 Barrantes-Vidal N, Grant P, Kwapil TR. The role of schizotypy in the study of the etiology of schizophrenia spectrum disorders. Schizophr Bull 2015; 41: S408-S416. [OpenAIRE]

7 Kwapil TR, Barrantes-Vidal N. Schizotypy: looking back and moving forward. Schizophr Bull 2015; 41: S366-S373. [OpenAIRE]

8 Kwapil TR, Gross GM, Silvia PJ, Barrantes-Vidal N. Prediction of psychopathology and functional impairment by positive and negative schizotypy in the Chapmans' ten-year longitudinal study. J Abnorm Psychol 2013; 122: 807-815.

9 Phillips LK, Seidman LJ. Emotion processing in persons at risk for schizophrenia. Schizophr Bull 2008; 34: 888-903. [OpenAIRE]

10 Pinkham AE, Penn DL, Perkins DO, Lieberman J. Implications for the neural basis of social cognition for the study of schizophrenia. Am J Psychiatry 2003; 160: 815-824.

11 Hooker C, Park S. Emotion processing and its relationship to social functioning in schizophrenia patients. Psychiatr Res 2002; 112: 41-50. [OpenAIRE]

12 Kring AM, Caponigro JM. Emotion in schizophrenia: where feeling meets thinking. Curr Direct Psychol Sci 2010; 19: 255-259. [OpenAIRE]

13 Kring AM, Moran EK. Emotional response deficits in schizophrenia: insights from affective science. Schizophr Bull 2008; 34: 819-834. [OpenAIRE]

14 Aleman A, Kahn RS. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Progr Neurobiol 2005; 77: 283-298.

15 Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry 2003; 54: 515-528.

71 references, page 1 of 5
Abstract
Animal models and human neuroimaging studies suggest that altered levels of glutamatergic metabolites within a corticolimbic circuit have a major role in the pathophysiology of schizophrenia. Rodent models propose that prefrontal glutamate dysfunction could lead to amygdala hyper-response to environmental stress and underlie hippocampal overdrive in schizophrenia. Here we determine whether changes in brain glutamate are present in individuals with high schizotypy (HS), which refers to the presence of schizophrenia-like characteristics in healthy individuals, and whether glutamate levels are related to altered corticolimbic response to emotion. Twenty-one healthy...
Subjects
mesheuropmc: nervous system
free text keywords: Biological Psychiatry, Original Article, /dk/atira/pure/subjectarea/asjc/2700/2738, Cellular and Molecular Neuroscience, /dk/atira/pure/subjectarea/asjc/2800/2803, /dk/atira/pure/subjectarea/asjc/2800/2804, Journal Article, Psychiatry and Mental health
Funded by
EC| VICARIOUSBRAIN
Project
VICARIOUSBRAIN
Cracking the code and flow of empathy
  • Funder: European Commission (EC)
  • Project Code: 312511
  • Funding stream: FP7 | SP2 | ERC
,
RCUK| Neurobiology of response to clozapine in treatment resistant schizophrenia
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: MR/L003988/1
  • Funding stream: MRC
71 references, page 1 of 5

1 van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L. A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 2009; 39: 179-195.

2 Linscott RJ, van Os J. An updated and conservative systematic review and metaanalysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychol Med 2013; 43: 1133-1149.

3 Nelson MT, Seal ML, Pantelis C, Phillips LJ. Evidence of a dimensional relationship between schizotypy and schizophrenia: a systematic review. Neurosci Biobehav Rev 2013; 37: 317-327.

4 Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 1991; 17: 555-564.

5 Raine A. Schizotypal personality: neurodevelopmental and psychosocial trajectories. Annu Rev Clin Psychol 2006; 2: 291-326.

6 Barrantes-Vidal N, Grant P, Kwapil TR. The role of schizotypy in the study of the etiology of schizophrenia spectrum disorders. Schizophr Bull 2015; 41: S408-S416. [OpenAIRE]

7 Kwapil TR, Barrantes-Vidal N. Schizotypy: looking back and moving forward. Schizophr Bull 2015; 41: S366-S373. [OpenAIRE]

8 Kwapil TR, Gross GM, Silvia PJ, Barrantes-Vidal N. Prediction of psychopathology and functional impairment by positive and negative schizotypy in the Chapmans' ten-year longitudinal study. J Abnorm Psychol 2013; 122: 807-815.

9 Phillips LK, Seidman LJ. Emotion processing in persons at risk for schizophrenia. Schizophr Bull 2008; 34: 888-903. [OpenAIRE]

10 Pinkham AE, Penn DL, Perkins DO, Lieberman J. Implications for the neural basis of social cognition for the study of schizophrenia. Am J Psychiatry 2003; 160: 815-824.

11 Hooker C, Park S. Emotion processing and its relationship to social functioning in schizophrenia patients. Psychiatr Res 2002; 112: 41-50. [OpenAIRE]

12 Kring AM, Caponigro JM. Emotion in schizophrenia: where feeling meets thinking. Curr Direct Psychol Sci 2010; 19: 255-259. [OpenAIRE]

13 Kring AM, Moran EK. Emotional response deficits in schizophrenia: insights from affective science. Schizophr Bull 2008; 34: 819-834. [OpenAIRE]

14 Aleman A, Kahn RS. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Progr Neurobiol 2005; 77: 283-298.

15 Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry 2003; 54: 515-528.

71 references, page 1 of 5
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publication . Article . 2017

Corticolimbic hyper-response to emotion and glutamatergic function in people with high schizotypy:a multimodal fMRI-MRS study

Modinos, G; McLaughlin, A; Egerton, A; McMullen, K; Kumari, V; Barker, G J; Keysers, C; Williams, S C R;