DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

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Ligthart, S.; Marzi, C.; Aslibekyan, S.; Mendelson, M.; Conneely, K.; Tanaka, T.; Colicino, E.; Waite, L.; Joehanes, R.; Guan, W.; Brody, J.; Elks, C.; Marioni, R.; Jhun, M.; Agha, G.; Bressler, J.; Ward-Caviness, C.; Chen, B.; Huan, T.; Bakulski, K.; Salfati, E.; Wahl, S.; Schramm, K.; Sha, J.; Hernandez, D.; Just, A.; Smith, J.; Sotoodehnia, N.; Pilling, L.; Pankow, J.; ... view all 86 authors
  • Publisher: BioMed Central
  • Journal: Genome Biology,volume 17,issue 1 (issn: 1474-7596, eissn: 1474-760X)
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  • Related identifiers: pmc: PMC5151130, doi: 10.1186/s13059-016-1119-5, doi: 10.1186/s13059-016-1119-5.
  • Subject: DNA methylation | Epigenome-wide association study | Method | Inflammation | Body mass index | C-reactive protein | Coronary heart disease | Diabetes | Body mass index; C-reactive protein; Coronary heart disease; Diabetes; DNA methylation; Epigenome-wide association study; Inflammation; Ecology, Evolution, Behavior and Systematics; Genetics; Cell Biology

Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeuti... View more