DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

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Ligthart, S. ; Marzi, C. ; Aslibekyan, S. ; Mendelson, M. ; Conneely, K. ; Tanaka, T. ; Colicino, E. ; Waite, L. ; Joehanes, R. ; Guan, W. ; Brody, J. ; Elks, C. ; Marioni, R. ; Jhun, M. ; Agha, G. ; Bressler, J. ; Ward-Caviness, C. ; Chen, B. ; Huan, T. ; Bakulski, K. ; Salfati, E. ; Wahl, S. ; Schramm, K. ; Sha, J. ; Hernandez, D. ; Just, A. ; Smith, J. ; Sotoodehnia, N. ; Pilling, L. ; Pankow, J. ... view all 86 authors (2016)

Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeuti... View more
  • References (29)
    29 references, page 1 of 3

    1. Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12:204-12.

    2. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11:98-107.

    3. Pepys MB. The acute phase response and C-reactive protein. Oxford Textbook Med. 1995;2:1527-33.

    4. Emerging Risk Factors Collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375:132-40.

    5. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesityrelated insulin resistance. J Clin Investig. 2003;112:1821.

    6. Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, et al. Metaanalysis of genome-wide association studies in > 80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011;123:731-8.

    7. Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:484-92.

    8. Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, et al. Accounting for population stratification in DNA methylation studies. Genet Epidemiol. 2014;38:231-41.

    9. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8.

    10. Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007;14:10-22.

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