NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.

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Kosugi, Shunichi; Yanagawa, Hiroshi; Terauchi, Ryohei; Tabata, Satoshi;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Computational Biology,volume 10,issue 9 (issn: 1553-734X, eissn: 1553-7358)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pcbi.1003841, pmc: PMC4168985
  • Subject: Computational Biology | Research Article | Biology and Life Sciences | Proteomics | Peptides | QH301-705.5 | Cell Nucleus | Cell Biology | Cellular Structures and Organelles | Biochemistry | Synthetic Peptides | Biology (General)
    mesheuropmc: fungi

The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs) in the cargo proteins, and modulates nuclear–cytoplasmic protein shuttling by antagonizing the nu... View more
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