publication . Article . 2016

Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications

Hui Xie; Zhenxing Wang; Liming Zhang; Qian Lei; Aiqi Zhao; Hongxiang Wang; Qiubai Li; Zhichao Chen; WenJie Zhang;
Open Access English
  • Published: 01 May 2016 Journal: PeerJ, volume 4 (issn: 2167-8359, eissn: 2167-8359, Copyright policy)
  • Publisher: PeerJ Inc.
Abstract
One of the major challenges of bone tissue engineering applications is to construct a fully vascularized implant that can adapt to hypoxic environments in vivo. The incorporation of proangiogenic factors into scaffolds is a widely accepted method of achieving this goal. Recently, the proangiogenic potential of mesenchymal stem cell-derived microvesicles (MSC-MVs) has been confirmed in several studies. In the present study, we incorporated MSC-MVs into alginate-polycaprolactone (PCL) constructs that had previously been developed for bone tissue engineering applications, with the aim of promoting angiogenesis and bone regeneration. MSC-MVs were first isolated from...
Subjects
free text keywords: Alginate, Mesenchymal stem cell, Microvesicle, R, Biotechnology, Bone tissue engineering, Angiogenesis, Polycaprolactone, Orthopedics, Medicine, Bioengineering
39 references, page 1 of 3

Aliotta, JM, Pereira, M, Li, M, Amaral, A, Sorokina, A, Dooner, MS, Sears, EH, Brilliant, K, Ramratnam, B, Hixson, DC, Quesenberry, PJ. Stable cell fate changes in marrow cells induced by lung-derived microvesicles. Journal of Extracellular Vesicles. 2012; 1: 18163 [OpenAIRE] [DOI]

Bao, W, Gao, M, Cheng, Y, Lee, HJ, Zhang, Q, Hemingway, S, Luo, Z, Krol, A, Yang, G, An, J. Biomodification of PCL scaffolds with Matrigel, HA, and SR1 enhances de novo ectopic bone marrow formation induced by rhBMP-2. BioResearch Open Access. 2015; 4 (1): 298-306 [OpenAIRE] [PubMed] [DOI]

Bian, S, Zhang, L, Duan, L, Wang, X, Min, Y, Yu, H. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. Journal of Molecular Medicine. 2014; 92 (4): 387-397 [PubMed] [DOI]

Bruno, S, Grange, C, Collino, F, Deregibus, MC, Cantaluppi, V, Biancone, L, Tetta, C, Camussi, G. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS ONE. 2012; 7 (3) [OpenAIRE] [DOI]

Chen, J, Liu, Z, Hong, MM, Zhang, H, Chen, C, Xiao, M, Wang, J, Yao, F, Ba, M, Liu, J, Guo, ZK, Zhong, J. Proangiogenic compositions of microvesicles derived from human umbilical cord mesenchymal stem cells. PLoS ONE. 2014; 9 (12) [OpenAIRE] [DOI]

Cheung, H-Y, Lau, K-T, Lu, T-P, Hui, D. A critical review on polymer-based bio-engineered materials for scaffold development. Composites Part B-Engineering. 2007; 38 (3): 291-300 [DOI]

Cocucci, E, Racchetti, G, Meldolesi, J. Shedding microvesicles: artefacts no more. Trends in Cell Biology. 2009; 19 (2): 43-51 [PubMed] [DOI]

Eirin, A, Riester, SM, Zhu, XY, Tang, H, Evans, JM, O’Brien, D, Van Wijnen, AJ, Lerman, LO. MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells. Gene. 2014; 551 (1): 55-64 [OpenAIRE] [PubMed] [DOI]

Gatti, S, Bruno, S, Deregibus, MC, Sordi, A, Cantaluppi, V, Tetta, C, Camussi, G. Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrology, Dialysis, Transplantation. 2011; 26 (5): 1474-1483 [DOI]

Gyorgy, B, Hung, ME, Breakefield, XO, Leonard, JN. Therapeutic applications of extracellular vesicles: clinical promise and open questions. Annual Review of Pharmacology and Toxicology. 2015; 55: 439-464 [OpenAIRE] [DOI]

Hergenreider, E, Heydt, S, Treguer, K, Boettger, T, Horrevoets, AJ, Zeiher, AM, Scheffer, MP, Frangakis, AS, Yin, X, Mayr, M, Braun, T, Urbich, C, Boon, RA, Dimmeler, S. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nature Cell Biology. 2012; 14 (3): 249-256 [OpenAIRE] [PubMed] [DOI]

Hettiaratchi, MH, Miller, T, Temenoff, JS, Guldberg, RE, McDevitt, TC. Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2. Biomaterials. 2014; 35 (25): 7228-7238 [OpenAIRE] [PubMed] [DOI]

Jang, CH, Kim, MS, Cho, YB, Jang, YS, Kim, GH. Mastoid obliteration using 3D PCL scaffold in combination with alginate and rhBMP-2. International Journal of Biological Macromolecules. 2013; 62: 614-622 [PubMed] [DOI]

Kim, M, Jung, WK, Kim, G. Bio-composites composed of a solid free-form fabricated polycaprolactone and alginate-releasing bone morphogenic protein and bone formation peptide for bone tissue regeneration. Bioprocess and Biosystems Engineering. 2013; 36 (11): 1725-1734 [PubMed] [DOI]

Kim, MS, Kim, G. Three-dimensional electrospun polycaprolactone (PCL)/alginate hybrid composite scaffolds. Carbohydrate Polymers. 2014; 114: 213-221 [PubMed] [DOI]

39 references, page 1 of 3
Abstract
One of the major challenges of bone tissue engineering applications is to construct a fully vascularized implant that can adapt to hypoxic environments in vivo. The incorporation of proangiogenic factors into scaffolds is a widely accepted method of achieving this goal. Recently, the proangiogenic potential of mesenchymal stem cell-derived microvesicles (MSC-MVs) has been confirmed in several studies. In the present study, we incorporated MSC-MVs into alginate-polycaprolactone (PCL) constructs that had previously been developed for bone tissue engineering applications, with the aim of promoting angiogenesis and bone regeneration. MSC-MVs were first isolated from...
Subjects
free text keywords: Alginate, Mesenchymal stem cell, Microvesicle, R, Biotechnology, Bone tissue engineering, Angiogenesis, Polycaprolactone, Orthopedics, Medicine, Bioengineering
39 references, page 1 of 3

Aliotta, JM, Pereira, M, Li, M, Amaral, A, Sorokina, A, Dooner, MS, Sears, EH, Brilliant, K, Ramratnam, B, Hixson, DC, Quesenberry, PJ. Stable cell fate changes in marrow cells induced by lung-derived microvesicles. Journal of Extracellular Vesicles. 2012; 1: 18163 [OpenAIRE] [DOI]

Bao, W, Gao, M, Cheng, Y, Lee, HJ, Zhang, Q, Hemingway, S, Luo, Z, Krol, A, Yang, G, An, J. Biomodification of PCL scaffolds with Matrigel, HA, and SR1 enhances de novo ectopic bone marrow formation induced by rhBMP-2. BioResearch Open Access. 2015; 4 (1): 298-306 [OpenAIRE] [PubMed] [DOI]

Bian, S, Zhang, L, Duan, L, Wang, X, Min, Y, Yu, H. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. Journal of Molecular Medicine. 2014; 92 (4): 387-397 [PubMed] [DOI]

Bruno, S, Grange, C, Collino, F, Deregibus, MC, Cantaluppi, V, Biancone, L, Tetta, C, Camussi, G. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS ONE. 2012; 7 (3) [OpenAIRE] [DOI]

Chen, J, Liu, Z, Hong, MM, Zhang, H, Chen, C, Xiao, M, Wang, J, Yao, F, Ba, M, Liu, J, Guo, ZK, Zhong, J. Proangiogenic compositions of microvesicles derived from human umbilical cord mesenchymal stem cells. PLoS ONE. 2014; 9 (12) [OpenAIRE] [DOI]

Cheung, H-Y, Lau, K-T, Lu, T-P, Hui, D. A critical review on polymer-based bio-engineered materials for scaffold development. Composites Part B-Engineering. 2007; 38 (3): 291-300 [DOI]

Cocucci, E, Racchetti, G, Meldolesi, J. Shedding microvesicles: artefacts no more. Trends in Cell Biology. 2009; 19 (2): 43-51 [PubMed] [DOI]

Eirin, A, Riester, SM, Zhu, XY, Tang, H, Evans, JM, O’Brien, D, Van Wijnen, AJ, Lerman, LO. MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells. Gene. 2014; 551 (1): 55-64 [OpenAIRE] [PubMed] [DOI]

Gatti, S, Bruno, S, Deregibus, MC, Sordi, A, Cantaluppi, V, Tetta, C, Camussi, G. Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrology, Dialysis, Transplantation. 2011; 26 (5): 1474-1483 [DOI]

Gyorgy, B, Hung, ME, Breakefield, XO, Leonard, JN. Therapeutic applications of extracellular vesicles: clinical promise and open questions. Annual Review of Pharmacology and Toxicology. 2015; 55: 439-464 [OpenAIRE] [DOI]

Hergenreider, E, Heydt, S, Treguer, K, Boettger, T, Horrevoets, AJ, Zeiher, AM, Scheffer, MP, Frangakis, AS, Yin, X, Mayr, M, Braun, T, Urbich, C, Boon, RA, Dimmeler, S. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nature Cell Biology. 2012; 14 (3): 249-256 [OpenAIRE] [PubMed] [DOI]

Hettiaratchi, MH, Miller, T, Temenoff, JS, Guldberg, RE, McDevitt, TC. Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2. Biomaterials. 2014; 35 (25): 7228-7238 [OpenAIRE] [PubMed] [DOI]

Jang, CH, Kim, MS, Cho, YB, Jang, YS, Kim, GH. Mastoid obliteration using 3D PCL scaffold in combination with alginate and rhBMP-2. International Journal of Biological Macromolecules. 2013; 62: 614-622 [PubMed] [DOI]

Kim, M, Jung, WK, Kim, G. Bio-composites composed of a solid free-form fabricated polycaprolactone and alginate-releasing bone morphogenic protein and bone formation peptide for bone tissue regeneration. Bioprocess and Biosystems Engineering. 2013; 36 (11): 1725-1734 [PubMed] [DOI]

Kim, MS, Kim, G. Three-dimensional electrospun polycaprolactone (PCL)/alginate hybrid composite scaffolds. Carbohydrate Polymers. 2014; 114: 213-221 [PubMed] [DOI]

39 references, page 1 of 3
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publication . Article . 2016

Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications

Hui Xie; Zhenxing Wang; Liming Zhang; Qian Lei; Aiqi Zhao; Hongxiang Wang; Qiubai Li; Zhichao Chen; WenJie Zhang;