Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications

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Xie, Hui; Wang, Zhenxing; Zhang, Liming; Lei, Qian; Zhao, Aiqi; Wang, Hongxiang; Li, Qiubai; Chen, Zhichao; Zhang, WenJie;
(2016)
  • Publisher: PeerJ Inc.
  • Journal: PeerJ,volume 4 (issn: 2167-8359, eissn: 2167-8359)
  • Related identifiers: pmc: PMC4878377, doi: 10.7717/peerj.2040
  • Subject: Alginate | Mesenchymal stem cell | Microvesicle | R | Biotechnology | Bone tissue engineering | Angiogenesis | Polycaprolactone | Orthopedics | Medicine | Bioengineering

One of the major challenges of bone tissue engineering applications is to construct a fully vascularized implant that can adapt to hypoxic environments in vivo. The incorporation of proangiogenic factors into scaffolds is a widely accepted method of achieving this goal.... View more
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