Adhesive F-actin Waves: A Novel Integrin-Mediated Adhesion Complex Coupled to Ventral Actin Polymerization

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Case, Lindsay B.; Waterman, Clare M.;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 6,issue 11 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3206032, doi: 10.1371/journal.pone.0026631
  • Subject: Research Article | Biology | Molecular Cell Biology | Cytoskeleton | Medicine | Extracellular Matrix Adhesions | Cellular Structures | Cytoskeletal Proteins | Q | R | Integrins | Cytochemistry | Proteins | Cell Adhesion | Science | Biochemistry | Extracellular Matrix
    mesheuropmc: macromolecular substances

At the leading lamellipodium of migrating cells, protrusion of an Arp2/3-nucleated actin network is coupled to formation of integrin-based adhesions, suggesting that Arp2/3-mediated actin polymerization and integrin-dependent adhesion may be mechanistically linked. Arp2... View more
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