Similar reliability and equivalent performance of female and male mice in the open field and water-maze place navigation task

Article English OPEN
Fritz, Ann-Kristina ; Amrein, Irmgard ; Wolfer, David P (2017)
  • Publisher: Wiley-Blackwell Publishing, Inc.
  • Journal: volume 175, issue 3, pages 380-391 (issn: 1552-4868, eissn: 1552-4876)
  • Related identifiers: doi: 10.5167/uzh-139004, doi: 10.1002/ajmg.c.31565, doi: 10.3929/ethz-b-000192542, pmc: PMC5638061
  • Subject: anxiety | Research Article | exploration | learning and memory | mouse model | Genetics(clinical), Genetics | 610 Medicine & health | anxiety; exploration; learning and memory; mouse model; sex differences | 570 Life sciences; biology | Institute of Anatomy | sex differences

Although most nervous system diseases affect women and men differentially, most behavioral studies using mouse models do not include subjects of both sexes. Many researchers worry that data of female mice may be unreliable due to the estrous cycle. Here, we retrospectiv... View more
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