Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin

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Wakamatsu, Kazumasa ; Tanaka, Hitomi ; Tabuchi, Keisuke ; Ojika, Makoto ; Zucca, Fabio ; Zecca, Luigi ; Ito, Shosuke (2014)
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: Molecules (issn: 1420-3049)
  • Related identifiers: doi: 10.3390/molecules19068039
  • Subject: aminohydroxyphenylacetic acid | HI reduction | Organic chemistry | QD241-441 | neuromelanin | aminohydroxyethylbenzene | aminohydroxyphenylethylamine | Parkinson’s disease

Neuromelanin (NM) is produced in dopaminergic neurons of the substantia nigra (SN) and in noradrenergic neurons of the locus coeruleus (LC). The synthesis of NM in those neurons is a component of brain aging and there is the evidence that this pigment can be involved i... View more
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