publication . Article . Other literature type . 2015

Airlift bioreactor for biological applications with microbubble mediated transport processes

Stephen J. Wilkinson; Mahmood K. H. Al-Mashhadani; William B. Zimmerman;
Open Access
  • Published: 01 Dec 2015 Journal: Chemical Engineering Science, volume 137, pages 243-253 (issn: 0009-2509, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Abstract Airlift bioreactors can provide an attractive alternative to stirred tanks, particularly for bioprocesses with gaseous reactants or products. Frequently, however, they are susceptible to being limited by gas–liquid mass transfer and by poor mixing of the liquid phase, particularly when they are operating at high cell densities. In this work we use CFD modelling to show that microbubbles generated by fluidic oscillation can provide an effective, low energy means of achieving high interfacial area for mass transfer and improved liquid circulation for mixing. The results show that when the diameter of the microbubbles exceeded 200 µm, the “downcomer” regio...
Subjects
free text keywords: Industrial and Manufacturing Engineering, Applied Mathematics, Chemistry(all), Chemical Engineering(all), Fluidic oscillation, Airlift bioreactor, COMSOL Mutiphysics, Surface-area-to-volume ratio, Chemistry, Drag, Microbubbles, Environmental engineering, Mechanics, Airlift, Mass transfer, Bioreactor, Draft tube, Buoyancy, engineering.material, engineering
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