Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

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Carles Lerin; Allison B. Goldfine; Tanner Boes; Manway Liu; Simon Kasif; Jonathan M. Dreyfuss; Ana Luisa De Sousa-Coelho; Grace Daher; Irini Manoli; Justin R. Sysol; Elvira Isganaitis; Niels Jessen; Laurie J. Goodyear; Kirk Beebe; Walt Gall; Charles P. Venditti; Mary-Elizabeth Patti;

Objective: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains unclear. Methods: To ... View more