publication . Article . 2009

Power of selective genotyping in genome-wide association studies of quantitative traits

Xing Chao; Xing Guan;
Open Access
  • Published: 01 Dec 2009 Journal: BMC Proceedings, volume 3 (eissn: 1753-6561, Copyright policy)
  • Publisher: Springer Nature
Abstract
<p>Abstract</p> <p>The selective genotyping approach in quantitative genetics means genotyping only individuals with extreme phenotypes. This approach is considered an efficient way to perform gene mapping, and can be applied in both linkage and association studies. Selective genotyping in association mapping of quantitative trait loci was proposed to increase the power of detecting rare alleles of large effect. However, using this approach, only common variants have been detected. Studies on selective genotyping have been limited to single-locus scenarios. In this study we aim to investigate the power of selective genotyping in a genome-wide association study s...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, SNP genotyping, Bioinformatics, Genotyping, Candidate gene, Genome-wide association study, Genetic association, Biology, Association mapping, Minor allele frequency, Quantitative trait locus, Genetics, Proceedings, Medicine, R, Science, Q
Funded by
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| NORTH AND CENTRAL TEXAS CLINICAL AND TRANSLATIONAL SCIENCE INITIATIVE (UL1)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1UL1RR024982-01
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES
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publication . Article . 2009

Power of selective genotyping in genome-wide association studies of quantitative traits

Xing Chao; Xing Guan;