publication . Article . 2013

Cadherin-12 contributes to tumorigenicity in colorectal cancer by promoting migration, invasion, adhersion and angiogenesis

Zhao, Jingkun; Li, Pu; Feng, Hao; Wang, Puxiongzhi; Zong, Yaping; Ma, Junjun; Zhang, Zhuo; Chen, Xuehua; Zheng, Minhua; Zhu, Zhenggang; ...
Open Access
  • Published: 01 Nov 2013 Journal: Journal of Translational Medicine, volume 11, page 288 (issn: 1479-5876, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Background Cadherin 12 (CDH12), which encodes a type II classical cadherin from the cadherin superfamily, may mediate calcium-dependent cell adhesion. It has been demonstrated that CDH12 could play an important role in the invasion and metastasis of salivary adenoid cystic carcinoma. We decided to investigate the relationship between CDH12 expression level and clinicopathologic variables in colorectal carcinoma (CRC) patients and to explore the functions of CDH12 in tumorigenesis in CRC. Methods The expression levels of CDH12 in colorectal carcinoma tissues were detected by immunohistochemistry. Real-time PCR and Western Blot were used to screen CDH12 high-expre...
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, Research, Cadherin12, Colorectal cancer, Cell proliferation, Cell migration, Cell invasion, Cell adhesion, Angiogenesis, Biochemistry, Genetics and Molecular Biology(all), Medicine(all)
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