The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

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van der Veen, Annemarthe G; Maillard, Pierre V; Schmidt, Jan Marten; Lee, Sonia A; Deddouche‐Grass, Safia; Borg, Annabel; Kjær, Svend; Snijders, Ambrosius P; Reis e Sousa, Caetano;
  • Publisher: John Wiley and Sons Inc.
  • Journal: The EMBO Journal,volume 37,issue 4 (issn: 0261-4189, eissn: 1460-2075)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.15252/embj.201797479, pmc: PMC5813259
  • Subject: viral infection | innate immunity | RIG‐I‐like receptor family | RNA Biology | RIG‐I‐like receptor family, RNA interference, double‐stranded RNA, innate immunity, viral infection | Articles | RNA interference | Immunology | Article | double‐stranded RNA
    mesheuropmc: fungi

Abstract In vertebrates, the presence of viral RNA in the cytosol is sensed by members of the RIG‐I‐like receptor (RLR) family, which signal to induce production of type I interferons (IFN). These key antiviral cytokines act in a paracrine and autocrine manner to induce... View more
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