publication . Article . 2018

An adaptive gene-based test for methylation data

Chong Wu; Jun Young Park; Weihua Guan; Wei Pan;
Open Access English
  • Published: 01 Sep 2018 Journal: BMC Proceedings, volume 12, issue Suppl 9 (eissn: 1753-6561, Copyright policy)
  • Publisher: BioMed Central
Abstract
Abstract DNA methylation plays an important role in normal human development and disease. In epigenome-wide association studies (EWAS), a univariate test for association between a phenotype and each cytosine-phosphate-guanine (CpG) site has been widely used. Given the number of CpG sites tested in EWAS, a stringent significance cutoff is required to adjust for multiple testing; in addition, multiple nearby CpG sites may be associated with the phenotype, which is ignored by a univariate test. These two factors may contribute to the power loss of a univariate test. As an alternative, we propose applying an adaptive gene-based test that is powerful in genome-wide a...
Subjects
free text keywords: Proceedings, Medicine, R, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Medicine, Genetics, Methylation, Genome-wide association study, Genetic association, DNA methylation, Multiple comparisons problem, CpG site, Univariate, business.industry, business, Phenotype
Funded by
NIH| Statistical Methods for Genomic Data
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 9R01GM113250-11A1
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Genetic Association and Personalized Medicine
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL105397-06
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Association analysis of rare variants with sequencing data
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL116720-05
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

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