publication . Article . 2015

Highly adaptive tests for group differences in brain functional connectivity

Kim, J; Pan, W; Initi, ADN;
Open Access English
  • Published: 01 Jan 2015 Journal: NeuroImage: Clinical (issn: 22131582, Copyright policy)
  • Publisher: The Authors. Published by Elsevier Inc.
  • Country: Mexico
Abstract
Highlights • Rigorous testing for genuinely altered functional networks between two groups • The proposed tests are high powered and general across a wide range of scenarios. • Data-driven penalized network estimation • Data-driven choice between correlations and partial correlations to describe association • Some key differences between network estimation and testing are highlighted.
Subjects
free text keywords: Alzheimer's Disease Neuroimaging Initiative, Brain, Humans, Alzheimer Disease, Magnetic Resonance Imaging, Brain Mapping, Data Interpretation, Statistical, Computer Simulation, Image Processing, Computer-Assisted, Aged, 80 and over, Female, Male, Neurosciences, Bioengineering, Neurological, and over, Covariance matrix, Graphical lasso, NBS, Precision matrix, rs-fMRI, Sparse estimation, SPU tests, Statistical power, Regular Article, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429, Functional magnetic resonance imaging, medicine.diagnostic_test, medicine, Data mining, computer.software_genre, computer, Neuroimaging, Statistical hypothesis testing, Computer science, Network model, Inference, Null hypothesis
Funded by
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| Statistical Methods for Genomic Data
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 9R01GM113250-11A1
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| New Machine Learning Tools for Biomedical Data
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R01GM081535-05
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Genetic Association and Personalized Medicine
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL105397-06
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| CORE-- CLINICAL
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30AG010129-11S1
  • Funding stream: NATIONAL INSTITUTE ON AGING
Communities
Neuroinformatics
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