Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits

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Qureshi, Mohd Javed; Mallikarjun, Chitneni; Kian, Wong Gan;
  • Publisher: Elsevier
  • Journal: Asian Journal of Pharmaceutical Sciences,volume 10,issue 1,pages40-56 (issn: 1818-0876)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.ajps.2014.08.003
  • Subject: Liquid loadable tablet | Self-microemulsifying drug delivery system (SMEDDS) | RM1-950 | Solid carrier system | Therapeutics. Pharmacology | Pharmaceutical Science | Pharmacodynamics studies | Pharmacology | Lovastatin | Neusilin® US2

The aim of present study was to formulate and evaluate a self-microemulsifying drug delivery systems (SMEDDS) containing lovastatin and to further explore the ability of porous Neusilin® US2 tablet as a solid carrier for SMEDDS. SMEDDS formulations of varying proportion... View more
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