Subject: insulin analogue | Diseases of the digestive system. Gastroenterology | Basal insulin analogue | Review Article | type 1 diabetes | type 2 diabetes | degludec | RC648-665 | RC799-869 | second-generation insulin analogue | Diseases of the endocrine glands. Clinical endocrinology
This paper reviews a novel insulin analogue, degludec, which has the potential to emerge as an ideal basal insulin. It reviews the limitations of existing basal insulin and analogues, and highlights the need for a newer molecule. The paper discusses the potential advant... View more
Jonassen, IB, Havelund, S, Ribel, U, Hoeg-Jensen, T, Steensgard, DB, Johansen, T. Insulin Degludec Is a New Generation Ultra-Long Acting Basal Insulin with a Unique Mechanism of Protraction Based on Multi-Hexamer Formation. American Diabetes Association (ADA) 70th Scientific Sessions: Abstract 39-OR. 2010
Nishimura, E, Rensen, AO, Falckhansen, BO, Stidsen, C, Olsen, GS, Schaumlffer, L. Insulin Degludec Is a New Generation Ultra-Long Acting Basal Insulin Designed To Maintain Full Metabolic Effect While Minimizing Mitogenic Potential. American Diabetes Association (ADA) 70th Scientific Sessions: Abstract 1406-P.
Heise, T, Hermanski, L, Nosek, L, Feldmann, A, Rasmussen, S, Stryhn, TK. Insulin degludec: Less pharmacodynamic variability than insulin glargine under steady-state conditions (Abstract). Diabetologia. 2010; 53 (Suppl 1): S387