Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD
Li, Nuomin; Liu, Kefu; Qiu, Yunjie; Ren, Zehui; Dai, Rongji; Deng, Yulin; Qing, Hong;
- Publisher: Frontiers Media S.A.
- Journal: Frontiers in Aging Neuroscience,volume 8 (issn: 1663-4365, eissn: 1663-4365)
Related identifiers: ,
- Subject: Neuroscience | Familial Alzheimer’s disease | Original Research | amyloid β-peptide | γ-secretase | presenilin1
Alzheimer disease (AD) is characterized by progressive memory loss, reduction in cognitive functions, and damage to the brain. The β-amyloid precursor protein can be sequentially cleaved by β- secretase and γ-secretase. Mutations in the presenilin1(PS1) are the most com... View more