publication . Review . Article . 2009

The Materials Science of Protein Aggregation

D.L. Cox; H. Lashuel; K.Y.C. Lee; R.R.P. Singh;
Open Access
  • Published: 02 Nov 2009
  • Publisher: Materials Research Society
  • Country: Switzerland
Abstract
<jats:title>Abstract</jats:title><jats:p>Numerous human diseases are associated with conformational change and aggregation of proteins, including Alzheimer's, Parkinson's, prion diseases (such as mad cow disease), familial amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), Huntington's, and type II (mature onset) diabetes. In many cases, it has been demonstrated that conformational change and aggregation can occur outside living cells and complex biochemical networks. Hence, approaches from materials and physical science have enhanced our understanding of the role of protein aggregation in these diseases at the molecular and nanoscale levels. In this ...
Subjects
free text keywords: Physical and Theoretical Chemistry, General Materials Science, Condensed Matter Physics, Lipid bilayer, Nanotechnology, Amyloid, Amyotrophic lateral sclerosis, medicine.disease, medicine, Conformational change, Disease, Protein structure, Amyloid disease, Protein aggregation, Chemistry
Related Organizations
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Review . Article . 2009

The Materials Science of Protein Aggregation

D.L. Cox; H. Lashuel; K.Y.C. Lee; R.R.P. Singh;