Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy.

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Huberfeld, Gilles; Menendez De La Prida, Liset; Pallud, Johan; Cohen, Ivan; Le Van Quyen, Michel; Adam, Claude; Clemenceau, Stéphane; Baulac, Michel; Miles, Richard;
  • Publisher: Nature Publishing Group
  • Identifiers: doi: 10.1038/nn.2790
  • Subject: [INFO.INFO-IM]Computer Science [cs]/Medical Imaging | epilepsy | networks and systems biology | Neurological Disorders | Plasticity | Synaptic Transmission | Neurophysiology
    mesheuropmc: nervous system diseases | nervous system

International audience; The mechanisms involved in the transition to an epileptic seizure remain unclear. To examine them, we used tissue slices from human subjects with mesial temporal lobe epilepsies. Ictal-like discharges were induced in the subiculum by increasing e... View more
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