Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy.
Huberfeld, Gilles; Menendez De La Prida, Liset; Pallud, Johan; Cohen, Ivan; Le Van Quyen, Michel; Adam, Claude; Clemenceau, Stephane; Baulac, Michel; Miles, Richard;
- Publisher: Nature Publishing Group
Related identifiers: - Subject: epilepsy | [INFO.INFO-IM]Computer Science [cs]/Medical Imaging | [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging | networks and systems biology | Neurological Disorders | Plasticity | Synaptic Transmission | Neurophysiologymesheuropmc: nervous system diseases | nervous system
International audience; The mechanisms involved in the transition to an epileptic seizure remain unclear. To examine them, we used tissue slices from human subjects with mesial temporal lobe epilepsies. Ictal-like discharges were induced in the subiculum by increasing e... View more
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