Role of co-repressor genomic landscapes in shaping the Notch response.

Article English OPEN
Stephen K K Chan ; Gustavo Cerda-Moya ; Robert Stojnic ; Kat Millen ; Bettina Fischer ; Silvie Fexova ; Lenka Skalska ; Maria Gomez-Lamarca ; Zoe Pillidge ; Steven Russell ; Sarah J Bray (2017)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Genetics, volume 13, issue 11 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: pmc: PMC5714389, doi: 10.1371/journal.pgen.1007096, doi: 10.17863/CAM.20237
  • Subject: Research Article | Transcription Factors | Cell Physiology | Notch Signaling | Drosophila melanogaster | Epigenetics | Genetic Loci | Invertebrate Genomics | Receptors, Notch | Graphs | QH426-470 | Genetics | Chromosome Biology | Genomics | Animals | Data Visualization | Co-Repressor Proteins | Drosophila Proteins | Repressor Proteins | Binding Sites | DNA-Binding Proteins | Biology and Life Sciences | RNA | Computer and Information Sciences | Ecdysone | Signal Transduction | Infographics | Genetic interference | Nucleic acids | Protein Binding | Chromatin | Cell Biology | Regulatory Sequences, Nucleic Acid | Biochemistry | Cell Signaling | Animal Genomics | RNA interference | Cell Binding | Gene Expression | Gene Expression Regulation, Developmental
    mesheuropmc: animal structures | integumentary system

Repressors are frequently deployed to limit the transcriptional response to signalling pathways. For example, several co-repressors interact directly with the DNA-binding protein CSL and are proposed to keep target genes silenced in the absence of Notch activity. Howeve... View more
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