Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination

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Matheson, Louise S. ; Bolland, Daniel J. ; Chovanec, Peter ; Krueger, Felix ; Andrews, Simon ; Koohy, Hashem ; Corcoran, Anne E. (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Immunology, volume 8 (issn: 1664-3224, eissn: 1664-3224)
  • Related identifiers: doi: 10.3389/fimmu.2017.01550/full, doi: 10.3389/fimmu.2017.01550, pmc: PMC5698286
  • Subject: V(D)J recombination | RC581-607 | IKAROS | Original Research | immunoglobulin kappa | chromatin state | PU.1 | Immunologic diseases. Allergy | epigenetic regulation | Immunology

V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We recently developed the DNA-based VDJ-seq assay ... View more
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