Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations

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Hatakeyama, Keiichi; Ohshima, Keiichi; Nagashima, Takeshi; Ohnami, Shumpei; Ohnami, Sumiko; Serizawa, Masakuni; Shimoda, Yuji; Maruyama, Koji; Akiyama, Yasuto; Urakami, Kenichi; Kusuhara, Masatoshi; Mochizuki, Tohru; Yamaguchi, Ken;
(2018)

Abstract Defective DNA polymerase ε (POLE) proofreading leads to extensive somatic mutations that exhibit biased mutational properties; however, the characteristics of POLE-mutated tumours remain unclear. In the present study, we describe a molecular profile using whole... View more
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