Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences

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Galson, Jacob D. ; Trück, Johannes ; Fowler, Anna ; Clutterbuck, Elizabeth A. ; Münz, Márton ; Cerundolo, Vincenzo ; Reinhard, Claudia ; van der Most, Robbert ; Pollard, Andrew J. ; Lunter, Gerton ; Kelly, Dominic F. (2015)
  • Publisher: Elsevier BV
  • Journal: EBioMedicine, volume 2, issue 12, pages 2,070-2,079 (issn: 2352-3964, eissn: 2352-3964)
  • Related identifiers: doi: 10.5167/uzh-133457, doi: 10.1016/j.ebiom.2015.11.034, pmc: PMC4703725
  • Subject: R | Research Article | 610 Medicine & health | Immunoglobulin repertoire | mAbs | Medical Clinic | Medicine | Vaccination | B cell repertoire

Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunog... View more