Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. : Fisetin disposition and metabolism in mice

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Touil , Yasmine , ; Auzeil , Nicolas ; Boulinguez , François ; Saighi , Hanane ; Regazzetti , Anne ; Scherman , Daniel ; Chabot , Guy , (2011)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.bcp.2011.07.097
  • Subject: MESH : Drug Combinations | [ SDV.CAN ] Life Sciences [q-bio]/Cancer | fisetin | MESH : Animals | MESH : Laminin | MESH : Flavones | MESH : Proteoglycans | MESH : Angiogenesis Inhibitors | MESH : Cell Line, Tumor | MESH : Cell Survival | pharmacokinetics | MESH : Carcinoma, Lewis Lung | MESH : Female | Flavonoid | cytotoxicity | geraldol | MESH : Antineoplastic Agents | MESH : Mice, Inbred C57BL | MESH : Endothelial Cells | MESH : Neoplasm Transplantation | metabolism | MESH : Collagen | MESH : Cell Movement | MESH : Flavonoids | [SDV.CAN] Life Sciences [q-bio]/Cancer | MESH : Glucuronides | MESH : Mice

International audience; Although the natural flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) has been recently identified as an anticancer agent with antiangiogenic properties in mice, its in vivo pharmacokinetics and metabolism are presently not characterized. Our pu... View more
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