Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. : Fisetin disposition and metabolism in mice

Article English OPEN
Touil, Yasmine,; Auzeil, Nicolas; Boulinguez, François; Saighi, Hanane; Regazzetti, Anne; Scherman, Daniel; Chabot, Guy,;
(2011)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.bcp.2011.07.097
  • Subject: MESH: Animals | MESH: Flavones | MESH : Drug Combinations | MESH: Drug Combinations | [ SDV.CAN ] Life Sciences [q-bio]/Cancer | fisetin | MESH: Cell Movement | MESH : Animals | MESH: Glucuronides | MESH : Laminin | MESH: Flavonoids | MESH : Flavones | MESH : Proteoglycans | MESH : Angiogenesis Inhibitors | MESH: Proteoglycans | MESH : Cell Line, Tumor | MESH: Collagen | [SDV.CAN]Life Sciences [q-bio]/Cancer | MESH : Cell Survival | pharmacokinetics | MESH: Mice, Inbred C57BL | MESH : Carcinoma, Lewis Lung | MESH : Female | MESH: Female | Flavonoid | cytotoxicity | MESH: Laminin | MESH: Antineoplastic Agents | geraldol | MESH: Endothelial Cells | MESH : Antineoplastic Agents | MESH : Mice, Inbred C57BL | MESH : Endothelial Cells | MESH: Carcinoma, Lewis Lung | MESH: Angiogenesis Inhibitors | MESH: Cell Survival | MESH: Neoplasm Transplantation | MESH: Mice | MESH : Neoplasm Transplantation | metabolism | MESH : Collagen | MESH : Cell Movement | MESH : Flavonoids | [SDV.CAN] Life Sciences [q-bio]/Cancer | MESH: Cell Line, Tumor | MESH : Glucuronides | MESH : Mice

International audience; Although the natural flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) has been recently identified as an anticancer agent with antiangiogenic properties in mice, its in vivo pharmacokinetics and metabolism are presently not characterized. Our pu... View more
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