Ocular surface wetness is regulated by trpm8-dependent cold thermoreceptors of the cornea

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Parra, Andrés; Madrid, Rodolfo; Echevarría, Diego; Olmo, Susana del; Morenilla-Palao, Cruz; Acosta, M. Carmen; Gallar, Juana; Dhaka, Ajay; Viana, Félix; Belmonte, Carlos;

Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors sense small oscillations in ambient temperature and change their discharge accordingly. Deletion of the cold-transducing ion channel Transient receptor potential cation channel ... View more