Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.

Article English OPEN
Susan M Lang ; Abid A Kazi ; Ly Hong-Brown ; Charles H Lang
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 7, issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3382153, doi: 10.1371/journal.pone.0038910
  • Subject: Animal Models | Signaling Cascades | Research Article | Molecular Cell Biology | Protein Metabolism | Immunity | Mouse | Inflammation | Proteins | Muscle | Immunology | Integrative Physiology | Biology | Signal Transduction | Muscle Biochemistry | Musculoskeletal System | Protein Synthesis | Medicine | Anatomy and Physiology | Q | R | Model Organisms | Clinical Immunology | Biochemistry | Science | Protein Kinase Signaling Cascade | Metabolism

The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery... View more
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