Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.
Susan M Lang
Abid A Kazi
Charles H Lang
- Publisher: Public Library of Science (PLoS)
(issn: 1932-6203, eissn: 1932-6203)
Animal Models | Signaling Cascades | Research Article | Molecular Cell Biology | Protein Metabolism | Immunity | Mouse | Inflammation | Proteins | Muscle | Immunology | Integrative Physiology | Biology | Signal Transduction | Muscle Biochemistry | Musculoskeletal System | Protein Synthesis | Medicine | Anatomy and Physiology | Q | R | Model Organisms | Clinical Immunology | Biochemistry | Science | Protein Kinase Signaling Cascade | Metabolism
The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery...