A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase

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Fu, Zhiyao; Abou-Samra, Abdul B.; Zhang, Ren; (2015)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports,volume 5 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep18502, pmc: PMC4685196
  • Subject: Article
    mesheuropmc: lipids (amino acids, peptides, and proteins) | nutritional and metabolic diseases

Lipasin/Angptl8 is a feeding-induced hepatokine that regulates triglyceride (TAG) metabolism; its therapeutical potential, mechanism of action, and relation to the lipoprotein lipase (LPL), however, remain elusive. We generated five monoclonal lipasin antibodies, among ... View more
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