Computational model of neuron-astrocyte interactions during focal seizure generation

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Reato, Davide; Cammarota, Mario; Parra, Lucas C.; Carmignoto, Giorgio;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Computational Neuroscience,volume 6 (issn: 1662-5188, eissn: 1662-5188)
  • Related identifiers: doi: 10.3389/fncom.2012.00081, pmc: PMC3467689
  • Subject: epilepsy | excitation/inhibition balance | Neuroscience | neuron-astrocyte interaction | Original Research Article | computational model | tripartite synapse

Empirical research in the last decade revealed that astrocytes can respond to neurotransmitters with Ca2+ elevations and generate feedback signals to neurons which modulate synaptic transmission and neuronal excitability. This discovery changed our basic understanding o... View more
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