Contribution of sleep to the repair of neuronal DNA double-strand breaks:evidence from flies and mice

Article English OPEN
Bellesi, M; Bushey, D; Chini, M; Tononi, G; Cirelli, C;
  • Publisher: Nature Publishing Group
  • Journal: volume 6issn: 2045-2322, eissn: 2045-2322
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1038/srep36804, pmc: PMC5103291
  • Subject: /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 | Research Support, N.I.H., Extramural | Journal Article | /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061 | Article | Research Support, Non-U.S. Gov't
    mesheuropmc: genetic processes | biological phenomena, cell phenomena, and immunity | fungi | enzymes and coenzymes (carbohydrates)

Exploration of a novel environment leads to neuronal DNA double-strand breaks (DSBs). These DSBs are generated by type 2 topoisomerase to relieve topological constrains that limit transcription of plasticity-related immediate early genes. If not promptly repaired, howev... View more