Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice
- Publisher: Nature Publishing Group
(issn: 2045-2322, eissn: 2045-2322)
/dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 | Research Support, N.I.H., Extramural | Journal Article | /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061 | Research Support, Non-U.S. Gov't | Article
mesheuropmc: genetic processes | biological phenomena, cell phenomena, and immunity | fungi | enzymes and coenzymes (carbohydrates)
Exploration of a novel environment leads to neuronal DNA double-strand breaks (DSBs). These DSBs are generated by type 2 topoisomerase to relieve topological constrains that limit transcription of plasticity-related immediate early genes. If not promptly repaired, howev...