publication . Article . 2016

Environmental Exposures and Parkinson’s Disease

Sirisha Nandipati; Irene Litvan;
Open Access English
  • Published: 01 Sep 2016 Journal: International Journal of Environmental Research and Public Health, volume 13, issue 9 (issn: 1661-7827, eissn: 1660-4601, Copyright policy)
  • Publisher: MDPI
Abstract
Parkinson’s disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown, but several environmental exposures have been associated with PD. Here, we summarize and examine the evidence for such environmental exposures. We completed a comprehensive review of human epidemiologic studies of pesticides, selected industrial compounds, and metals and their association with PD in PubMed and Google Scholar until April 2016. Most studies show that rotenone and paraquat are linked to increased P...
Subjects
free text keywords: environment and Parkinson’s disease, toxins and Parkinson’s disease, R, pesticides and Parkinson’s disease, Review, Medicine
Funded by
NIH| SHORT TERM RESEARCH TRAINING
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T35HL007491-19
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| CORE--CLINICAL
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50AG005131-25
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01NS086659-03
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| Admin Core - The Frontotemporal Lobar Degeneration Clinical Research Consortium
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U54NS092089-01
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
134 references, page 1 of 9

Ziemssen, T., Reichmann, H.. Non-motor dysfunction in Parkinson’s disease. Parkinsonism Relat. Disord.. 2007; 13: 323-332 [PubMed] [DOI]

Schapira, A.. Etiology of Parkinson’s disease. Neurology. 2006; 66: S10-S23 [PubMed] [DOI]

Lesage, S., Brice, A.. Parkinson’s disease: From monogenic forms to genetic suscpetibility factors. Hum. Mol. Genet.. 2009; 18: R48-R59 [PubMed] [DOI]

Goldman, S.. Environmental toxins and Parkinson’s disease. Annu. Rev. Pharmacol. Toxicol.. 2014; 54: 141-164 [PubMed] [DOI]

Winklhofer, K.F., Haass, C.. Mitochondrial dysfunction in Parkinson’s disease. Biochim. Biophys. Acta. 2010; 1802: 29-44 [OpenAIRE] [PubMed] [DOI]

Chu, Y., Dodiya, H., Aebischer, P., Olanow, C.W., Kordower, J.. Alterations in lysosomal and proteasomal markers in Parkinson’s disease: Relationship to alpha-synuclein inclusions. Neurobiol. Dis.. 2009; 35: 385-398 [OpenAIRE] [PubMed] [DOI]

Dehay, B., Martinez-Vicente, M., Caldwell, G.A., Caldwell, K.A., Yue, Z., Cookson, M.R., Klein, C., Vila, M., Bezard, E.. Lysosomal impairment in Parkinson’s disease. Mov. Disord.. 2013; 28: 725-732 [OpenAIRE] [PubMed] [DOI]

Chan, C.S., Gertler, T., Surmeier, D.J.. Calcium homeostasis, selective vulnerability and Parkinson’s disease. Trends Neurosci.. 2009; 32: 249-256 [OpenAIRE] [PubMed] [DOI]

Hirsch, E.C., Vyas, S., Hunot, S.. Neuroinflammation in Parkinson’s disease. Parkinsonism Relat. Disord.. 2012; 18: S210-S212 [PubMed] [DOI]

Lucking, C.B., Brice, A.. Alpha-synuclein and Parkinson’s disease. Cell. Mol. Life Sci. CMLS. 2000; 57: 1894-1908 [PubMed] [DOI]

Jenner, P.. Oxidative stress in Parkinson’s disease. Ann. Neurol.. 2003; 53: S26-S38 [PubMed] [DOI]

Hawkes, C.H., Tredeci, K.D., Braak, H.. Review: Parkinson’s disease: A dual-hit hypothesis. Neuropathol. Appl. Neurobiol.. 2007; 33: 599-614 [PubMed] [DOI]

Langston, J.W.. MPTP and Parkinson’s disease. Trends Neurosci.. 1985; 8: 79-83 [DOI]

Schober, A.. Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP. Cell Tissue Res.. 2004; 318: 215-224 [PubMed] [DOI]

Gainetdinov, R.R., Fumagalli, F., Jones, S.R., Caron, M.G.. Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter. J. Neurochem.. 1997; 69: 1322-1325 [PubMed] [DOI]

134 references, page 1 of 9
Abstract
Parkinson’s disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown, but several environmental exposures have been associated with PD. Here, we summarize and examine the evidence for such environmental exposures. We completed a comprehensive review of human epidemiologic studies of pesticides, selected industrial compounds, and metals and their association with PD in PubMed and Google Scholar until April 2016. Most studies show that rotenone and paraquat are linked to increased P...
Subjects
free text keywords: environment and Parkinson’s disease, toxins and Parkinson’s disease, R, pesticides and Parkinson’s disease, Review, Medicine
Funded by
NIH| SHORT TERM RESEARCH TRAINING
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T35HL007491-19
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| CORE--CLINICAL
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50AG005131-25
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01NS086659-03
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| Admin Core - The Frontotemporal Lobar Degeneration Clinical Research Consortium
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U54NS092089-01
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
134 references, page 1 of 9

Ziemssen, T., Reichmann, H.. Non-motor dysfunction in Parkinson’s disease. Parkinsonism Relat. Disord.. 2007; 13: 323-332 [PubMed] [DOI]

Schapira, A.. Etiology of Parkinson’s disease. Neurology. 2006; 66: S10-S23 [PubMed] [DOI]

Lesage, S., Brice, A.. Parkinson’s disease: From monogenic forms to genetic suscpetibility factors. Hum. Mol. Genet.. 2009; 18: R48-R59 [PubMed] [DOI]

Goldman, S.. Environmental toxins and Parkinson’s disease. Annu. Rev. Pharmacol. Toxicol.. 2014; 54: 141-164 [PubMed] [DOI]

Winklhofer, K.F., Haass, C.. Mitochondrial dysfunction in Parkinson’s disease. Biochim. Biophys. Acta. 2010; 1802: 29-44 [OpenAIRE] [PubMed] [DOI]

Chu, Y., Dodiya, H., Aebischer, P., Olanow, C.W., Kordower, J.. Alterations in lysosomal and proteasomal markers in Parkinson’s disease: Relationship to alpha-synuclein inclusions. Neurobiol. Dis.. 2009; 35: 385-398 [OpenAIRE] [PubMed] [DOI]

Dehay, B., Martinez-Vicente, M., Caldwell, G.A., Caldwell, K.A., Yue, Z., Cookson, M.R., Klein, C., Vila, M., Bezard, E.. Lysosomal impairment in Parkinson’s disease. Mov. Disord.. 2013; 28: 725-732 [OpenAIRE] [PubMed] [DOI]

Chan, C.S., Gertler, T., Surmeier, D.J.. Calcium homeostasis, selective vulnerability and Parkinson’s disease. Trends Neurosci.. 2009; 32: 249-256 [OpenAIRE] [PubMed] [DOI]

Hirsch, E.C., Vyas, S., Hunot, S.. Neuroinflammation in Parkinson’s disease. Parkinsonism Relat. Disord.. 2012; 18: S210-S212 [PubMed] [DOI]

Lucking, C.B., Brice, A.. Alpha-synuclein and Parkinson’s disease. Cell. Mol. Life Sci. CMLS. 2000; 57: 1894-1908 [PubMed] [DOI]

Jenner, P.. Oxidative stress in Parkinson’s disease. Ann. Neurol.. 2003; 53: S26-S38 [PubMed] [DOI]

Hawkes, C.H., Tredeci, K.D., Braak, H.. Review: Parkinson’s disease: A dual-hit hypothesis. Neuropathol. Appl. Neurobiol.. 2007; 33: 599-614 [PubMed] [DOI]

Langston, J.W.. MPTP and Parkinson’s disease. Trends Neurosci.. 1985; 8: 79-83 [DOI]

Schober, A.. Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP. Cell Tissue Res.. 2004; 318: 215-224 [PubMed] [DOI]

Gainetdinov, R.R., Fumagalli, F., Jones, S.R., Caron, M.G.. Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter. J. Neurochem.. 1997; 69: 1322-1325 [PubMed] [DOI]

134 references, page 1 of 9
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publication . Article . 2016

Environmental Exposures and Parkinson’s Disease

Sirisha Nandipati; Irene Litvan;