The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism

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Kumar, Hemant ; Lim, Hyung-Woo ; More, Sandeep Vasant ; Kim, Byung-Wook ; Koppula, Sushruta ; Kim, In Su ; Choi, Dong-Kug (2012)
  • Publisher: Molecular Diversity Preservation International (MDPI)
  • Journal: International Journal of Molecular Sciences, volume 13, issue 8, pages 10,478-10,504 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: doi: 10.3390/ijms130810478, pmc: PMC3431873
  • Subject: Chemistry | free radicals | nrf2 | QD1-999 | Review | mitochondrial dysfunction | aging | Parkinson’s disease | α-synuclein | Biology (General) | QH301-705.5

Free radical production and their targeted action on biomolecules have roles in aging and age-related disorders such as Parkinson’s disease (PD). There is an age-associated increase in oxidative damage to the brain, and aging is considered a risk factor for PD. Dopamine... View more
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