Adaptation and preadaptation of Salmonella enterica to bile

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Aussel, Laurent ; Casadesús Pursals, Josep ; Cota García, Ignacio ; Hernández Piñero, Sara Belén ; Ducret, Adrien (2012)
  • Publisher: Public Library of Science (PLoS)
  • Journal: volume 8, issue 1 (issn: 1553-7404, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1002459, pmc: PMC3261920
  • Subject: QH426-470 | Research Article | Biology | Genetics | Microbiology
    mesheuropmc: digestive system

Bile possesses antibacterial activity because bile salts disrupt membranes, denature proteins, and damage DNA. This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile. Sublethal concentrations of the bile salt sodium deoxycholate (D... View more
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