Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis

Other literature type, Article English OPEN
Spratt, B G; Zhang, Q Y; Jones, D M; Hutchison, A; Brannigan, J A; Dowson, C G;
  • Publisher: National Academy of Sciences
  • Related identifiers: doi: 10.1073/pnas.86.22.8988, pmc: PMC298417
  • Subject: Bacterial Proteins | Research Article | Neisseria meningitidis | Penicillin Resistance | MULTIDISCIPLINARY SCIENCES | Molecular Sequence Data | Hexosyltransferases | Oligonucleotide Probes | Amino Acid Sequence | Muramoylpentapeptide Carboxypeptidase | Multienzyme Complexes | Neisseria | Sequence Homology, Nucleic Acid | Science & Technology - Other Topics | Base Sequence | Peptidyl Transferases | MD Multidisciplinary | Genes, Bacterial | Carrier Proteins | Neisseria gonorrhoeae | Penicillin-Binding Proteins | Science & Technology | Acyltransferases | Penicillins
    mesheuropmc: polycyclic compounds

Non-beta-lactamase-producing, penicillin-resistant strains of Neisseria meningitidis produce altered forms of penicillin-binding protein 2 that have decreased affinity for penicillin. The sequence of the penicillin-binding protein 2 gene (penA) from a penicillin-resista... View more
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