Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study

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Legason, Ismail D.; Pfeiffer, Ruth M.; Udquim, Krizia-Ivana; Bergen, Andrew W.; Gouveia, Mateus H.; Kirimunda, Samuel; Otim, Isaac; Karlins, Eric; Kerchan, Patrick; Nabalende, Hadijah; Bayanjargal, Ariunaa; Emmanuel, Benjamin; Kagwa, Paul; Talisuna, Ambrose O.; Bhatia, Kishor; Yeager, Meredith; Biggar, Robert J.; Ayers, Leona W.; Reynolds, Steven J.; Goedert, James J.; Ogwang, Martin D.; Fraumeni, Joseph F.; Prokunina-Olsson, Ludmila; Mbulaiteye, Sam M.;
(2017)

Background: Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship between sickle cell trait (SCT) and eBL, which supports that between malaria and eBL, has been repo... View more
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